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In addition, the observed differential 1-MNA steady-state levels following NNMT inhibition may reflect differential transcriptional regulation of cellular metabolic pathways across the various stages of 3T3-L1 differentiation;[38] for example, aldehyde oxidase (AOX)-mediated degradation of 1-MNA may be more pronounced in pre-adipocytes compared to adipocytes, thereby synergistically reducing 1-MNA levels to a greater extent in pre-adipocytes compared to adipocytes
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For treating a deficiency, injections are usually given frequently at the start, for example, several times per week or every other day for a couple of weeks, to quickly build up body stores
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