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[22] concluded that there was no significant difference in the live birth rate between the group of TPOAb-positive euthyroid women who received L-T4 tablets (50 μg/d) for six months and the group of TPOAb-positive euthyroid women who were treated with placebo alone

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Further mechanistic studies are also needed to isolate and characterize the bioactive molecules responsible for the observed inhibition, for example, through metabolomics and in vitro assays with purified TMA lyase (CutC/D) to clarify inhibition kinetics

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