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38 Risk of major adverse cardiovascular events (MACE) was analyzed in a meta-analysis for all SURPASS trials and showed no statistically significant differences between pooled tirzepatide groups and control groups (hazard-ratio (HR) 0.80 [95% CI: 0.57–1.11])

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AML-12 cell lysates were deproteinized with 5% sulfosalicylic acid (SSA) and centrifuged at 10,000 × g for 10 min at 4 °C to remove precipitated proteins

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