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Efficient uptake of iodine, selenium, iron, and zinc—micronutrients governing thyrocyte function from hormone synthesis (iodination, TPO activity) to peripheral activation (DIO-mediated T 3 generation)—serves as a therapeutic target in hypothyroidism and Hashimoto’s thyroiditis, particularly in populations with coexisting deficiencies (Shulhai et al., 2024)

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5f, quantification: Fig