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The two compounds engage GH biology from opposite directions: AOD-9604 is downstream of GH release — a fragment that retains specific GH biological activity (lipolysis) without engaging GH receptors Tesamorelin is upstream of GH release — a GHRH analog that prompts the pituitary to release endogenous GH Origin Comparison This is a fundamental distinction

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[DOI] [PubMed] [Google Scholar] 84.Seiwerth S., Rucman R., Turkovic B., Sever M., Klicek R., Radic B., Drmic D., Stupnisek M., Misic M., Vuletic L.B., et al