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Cytosolic mtDNA levels rise within hours and can persist for days, activating cyclic GMP-AMP Synthase-Stimulator of Interferon Genes (cGAS-STING) to induce type-I interferon and NF-κB programs that link acute injury to chronic inflammation and senescence

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Circadian Rhythms and Antioxidant Defense Timing Glutathione metabolism follows circadian patterns, with peak synthesis occurring in early morning and declining through evening