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Further, to our surprise, when the KP biofilm was grown in the presence of GH-B2, the MBEC of meropenem was ∼2 μg/mL, suggesting that the enzyme prevented biofilm formation, rendering KP cells accessible to the antibiotic (Supplementary Fig

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While the animal model treated with PBS did not show any signs for ROS, high amounts of fluorescence signals in the tissue from the animal treated with NP4 were observed (Supplementary Fig