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Beran M, Estey E, O'Brien S, Cortes J, Koller CA, Giles FJ, Kornblau S, Andreeff M , Vey N, Pierce SR, Hayes K, Wong GC, Keating M, Kantarjian H

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By inhibiting FLIP, promoting DISC (death signal inducing complex) assembly by FLIP, activating caspase-8, transmitting the apoptotic signal to the mitochondria, and inducing the release of cytochrome C from the mitochondria into the cytoplasm, H