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The process of cellular senescence involves multiple factors, including DNA damage, telomere shortening, and epigenetic changes, which lead to cell cycle arrest and ultimately result in cellular senescence (Zhang et al., 2024)

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One phase recovers within 2 hours after removal of morphine and is thought to be recovery from desensitization as it is produced by either agonist removal or inhibition of protein kinase C (PKC) (Bailey et al., 2009a)