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However, statins have been reported to prevent the activation and proliferation of T cells interacting with agonistic anti-CD3 monoclonal antibody (mAb) or Staphylococcus aureus enterotoxin (SEB), an impact attributed to the deficiency of pathways regulated by small Ras-like GTPases in T-cell receptor (TCR) signaling for the former stimulus through lymphocyte function-associated antigen 1 (LFA-1) blockage [47, 48]

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These can include dry skin, higher risk of skin infections, and (ironically) hyperpigmentation, i.e., increased skin darkening