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Research in pulmonary hypertension models has found that NNMT activity increases progressively in affected lung and liver tissue, with elevated MNA levels also observed in the plasma of patients with idiopathic pulmonary hypertension, establishing NNMT as a pathway of interest in cardiovascular disease independent of the metabolic research

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The MTHFR gene is extremely well researched, with over 6,000 studies investigating the C677T variant

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