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DHT-inducible DKK1 produced by balding DP cells promotes apoptosis of neighboring follicular keratinocytes in vitro, together with the higher expression of DKK1 in balding compared with the haired scalp, suggesting that DKK1 may be one of the key factors involved in the pathogenesis of AGA 41

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however, much evidence shows that pathways involving nerves connecting the nasal passages to the brain and spinal cord are essential