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Leptin to soluble leptin receptor ratio decreased at 32 weeks in the CagriSema group versus other groups reflecting increased leptin sensitivity [10]

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To prevent liver’s clearance and improve transfection efficiency, antibody-based (i.e., T cell membrane markers, CD3, CD4, CD8, CD5, etc.) membrane modifications can guide LNP retention in specific extrahepatic tissues 46,47,48,49