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Removal of breast cancer cells from extracellular matrix (ECM) and local invasion and migration initiation: Disruption of the connection of the cell to ECM through cellular adhesion proteins such as integrins, resulting in the dissociation of cancer cells from adjacent cells and the basement membrane, describes how metastasis begins (118)

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In saline, APP treatment also induced significant changes in NO, total NO, and ROS contents in a treatment time-dependent manner, with their concentrations reaching 90.55 ± 15.90 µM (Fig