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Neuroprotection research includes hippocampal ischemia-reperfusion models in rats (PMID 32558293) and investigations into the brain-gut axis as a candidate explanatory framework for the broad effects observed across tissue types (PMID 27138887)

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The key difference is in dosing, as tirzepatide escalation starts at 2.5mg rather than 0.25mg, which means much larger weekly doses and faster vial consumption